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Karen Zaghiyan, MD, FACS, FASCRS

Colorectal Surgeon located in Los Angeles, CA

Karen Zaghiyan, MD, FACS, FASCRS, is a board-certified colorectal surgeon practicing at her practice in Los Angeles, California. Dr. Zaghiyan’s interests lie in providing minimally invasive treatments for conditions of the colon, rectum, and anus through the use of robotic, laparoscopic, transanal and natural orifice techniques.

Her special interests in colorectal cancer and inflammatory bowel disease (IBD) have driven her success as one of the early adopters and innovators of transanal total mesorectal excision (taTME) and transanal ileal pouch-anal anastomosis (taIPAA) for patients with rectal cancer and inflammatory bowel disease.

Dr. Zaghiyan is the Director of the Colorectal Cancer Program at the Samuel Oschin Comprehensive Cancer Institute at Cedars Sinai Medical Center in Los Angeles. She is also the Associate Professor of Surgery and Associate Program Director for the Colorectal Residency Program at Cedars Sinai Medical Center. 

Dr. Zaghiyan graduated magna cum laude with a Bachelor of Science in Biology from the University of California, Los Angeles. She then completed medical school at the University of California, San Diego before pursuing her general surgery residency and colon and rectal surgery fellowship at Cedars-Sinai Medical Center in Los Angeles. During this time, she traveled to Singapore for additional training from international leaders in her field prior to return to Los Angeles to start her practice. 

Dr. Zaghiyan is an innovator and expert in her field who is regularly invited to speak and teach at top national and international conferences. She is the principal investigator of numerous local, national and international research projects with the goal to improve the care of patients with colorectal conditions. Her research focuses on practical issues in colorectal surgery such as the use of local nerve blocks to minimize surgical pain and improve recovery, early diet advancement, optimal steroid dose after IBD surgery, and quality of life after J-pouch surgery, to name a few. 

Dr. Zaghiyan remains dedicated to making advancements in her field, which directly impacts the well-being of her patients. With her clinical and research expertise along with her commitment to providing the highest-quality care, Dr. Zaghiyan delivers the most cutting-edge treatments for men and women with colon and rectal diseases.


Anal Fissure

Anal Fistula


Colon Cancer 

Crohn's Disease


Fecal Incontinence


J Pouch Surgery

Pilonidal Cyst

Rectal Cancer 

Rectal Prolapse

Robotic Colorectal Surgery

Transanal Total 

Mesorectal Excision

Transanal Minimally Invasive Surgery

Ulcerative Colitis 

Dr Zaghiyan Intro

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Dr. Zaghiyan named among Los Angeles Top Doctors

Hemorrhoids - How to Prevent & Treat Without Surgery

We're all born with hemorrhoids. With time, pressure on these veins can lead to swelling and symptoms. Simple lifestyle changes can help undo most early damage and non-invasive hemorrhoid treatments can prevent progression and avoid hemorrhoid surgery.

A Letter to Patients With Crohn's Disease Considering Surgery

Deciding on surgery for Crohn's disease can be daunting. A board-certified colorectal surgeon in Los Angeles, and expert in inflammatory bowel disease and cancer surgery, Dr Zaghiyan writes a letter to describe how her minimally invasive approach may help.

Image by Glen Kelp from Pixabay
New Treatments for Anal Fistula - Stem Cells & More

Anal fistula can occur in anyone but individuals with Crohn's are at higher risk. New treatments including stem cells may change the treatment landscape. Learn from Dr Zaghiyan, a leading expert in the field of anal fistula surgery and stem cells.


Words from our patients

  • Yelp

    "Dr. Zaghiyan is wonderful! She has great bedside manner and knows what she's talking about. She listens and gets you in and out in a timely manner."

    Eden G.
  • Yelp

    "She saved my life. Thank you, my angel on earth, Dr. Z! You will always be in my thoughts... especially every time I'm able to enjoy a meal. I'm thankful to be alive."

    Annette G.
  • 5 star

    "Dr. Karen Zaghiyan is amazing. She has bedside manners. She takes the time and treat her patients as if they were part of her own family."

    Dana H.
  • Yelp

    "Dr. Z is an incredible doctor. Extremely knowledgeable, articulate and kind. Highly recommend her for her attention to detail and overall care."

    Jessica B.
  • 5 star

    "Wonderful Doctor. Very knowledgable, professional and nice. Highly recommend. Thank you Doctor Karen."

    Tanya K.


Karen Zaghiyan MD
8737 Beverly Blvd, Suite 101
Los Angeles, CA 90048
Phone: 310-289-9224

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